What is Skin Needling (Mesotherapy)? It’s a procedure that uses injections of vitamins, minerals, plant extracts, and other chemicals to rejuvenate your skin. It’s considered non-invasive because it doesn’t use skin cutting techniques to get the treatment done like other skin rejuvenation surgeries. So what exactly happens in a Mesotherapy session? It involves your skin being pricked with micro-needles from a medical gun, a process called Skin Needling. A special mix of nutrients are injected directly under your skin in the area required. The process is quick with little to no pain, and there’s almost no recovery time required.